Journal of Oral Tissue Engineering

ORIGINAL ARTICLE
 Bone Response after Tooth Extraction in Ovariectomized Rats

 Ryoko KUSUNOKI1, Joji OKAZAKI2 and Yutaka KOMASA2

 1Graduate School of Dentistry (Geriatric Dentistry), Osaka Dental University, JAPAN, 2Department of Geriatric Dentistry, Osaka Dental University, JAPAN

J Oral Tissue Engin 2006;4(2): 89-100
Full Text. DOI https://doi.org/10.11223/jarde.4.89
SYNOPSIS
Few studies have investigated the bone healing of the extracted socket in osteo-porosis. The aim of this study is to evaluate the bone response of mandibular in-cisor extraction in ovariectomized rats using titanium alloy screw.
Ovariectomy (OVX) or sham operation was performed at 9 weeks of age. We measured animal body weights each three week to observe the development situation. The titanium alloy screws were placed into the cavities of the mandibular incisor extraction. At 3, 6 and 9 weeks post-insertion, histological observation were performed.
Findings in the healing process of the extraction socket after insertion of a ti-tanium screw differed between the Control and OVX groups.
The study results indicate that osteoporosis has affect on socket healing after the extraction of ovariectomized rat mandibular incisors. Therefore we may need to consider osteoporosis in patients of bone response after tooth extraction.

Key words:tooth extraction socket, ovariectomy, rat