Journal of Oral Tissue Engineering



ORIGINAL ARTICLE
Accelerated Effect of MatriStem on Dentin Regeneration in Rats

Keiko ONJI1,2, Toshiyuki KOIKE1,3,
Mohammad Ali Akbor POLAN4, Md Riasat HASAN1,
Bayarchimeg ALTERHISHIG1, Yaxin RAO1, Youjin QIU1,
Yasuhiro MATSUDA1, Kazuhisa BESSHO5
and Takashi SAITO1


1Division of Clinical Cariology and Endodontology,
Department of Oral Rehabilitation, School of Dentistry,
Health Sciences University of Hokkaido, Hokkaido, Japan
2Takeru Dental Clinic, Tokyo, Japan
3K's Dental Clinic, Osaka, Japan
4Department of Children Preventive and Community Dentistry,
Dhaka Dental College, Dhaka, Bangladesh
5Department of Oral and Maxillofacial Surgery,
Graduate School of Medicine, Kyoto University, Kyoto, Japan

J Oral Tissue Engin 2020; 18(1): 23-28.

SYNOPSIS
The purpose of the present study was to investigate the effect of MatriStem derived from porcine bladder on reparative dentin formation and pulp inflammation in vivo compared with mineral trioxide aggregate and calcium hydroxide that have been used for vital pulp therapy. Exposed pulp tissue in the maxilla first molar of 8-week-old Wistar rats was covered with those materials. The rats were sacrificed 4 weeks after the operation. We performed histological examination of hematoxylin and eosin-stained sections of teeth that underwent direct pulp capping, followed by morphometric analysis of formed reparative dentin and evaluation of pulp inflammation. At 4 weeks, MatriStem formed highly compact, intensively reparative dentin with dentinal tubules. MatriStem induced less pulp inflammation than calcium hydroxide. This study suggests that MatriStem is a biocompatible, biodegradable, and bioactive material with growth factors such as bone morphogenetic proteins for dentin regeneration.

Key words: MatriStem, extracellular matrix, dentin regeneration, direct pulp capping, reparative dentin formation


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J-Stage https://www.jstage.jst.go.jp/article/jarde/18/1/18_23/_article

DOI https://doi.org/10.11223/jarde.18.23