SYNOPSISHuman
Υδ T cells are subdivided into two main subsets, V
Υ1 and V
Υ2 T cells, based on the expression of the V
ΥT cell receptor (TCR) subunit. Most peripheral blood
Υ9VδT cells express both V
Υ2 and V
Υ;9 TCR subunits. V
Υ9Vδ2T cells are known to play a key role in immunity against microbial infection and tumors via recognition of non-peptide phospho-antigens. Here, we investigated the anti-gen-independent cytokine-dependent activation of
ex vivo expanded V
Υ9Vδ2 T cells. We found that IL-15, but not IL-2, induced cell division in
ex vivo expanded V
Υ9Vδ2 T cells in the absence of antigen stimulation.
Key words: IL-15, VΥ9Vδ2 T cells, proliferation
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