Journal of Oral Tissue Engineering

IL-15, but Not IL-2, Induces Proliferative Activity of Human Ex Vivo Expanded VΥ9Vδ2 T Cells

Eisuke DOMAE1, Kaname TSUJI2, Yuya HIRAI3, Yoshihiro YOSHIKAWA1, Aiko KAMADA1, Shosuke MORITA2, Seiji GODA4, and Takashi IKEO1

1Department of Biochemistry, 2First Department of Oral and Maxillofacial Surgery,
3Department of Biology, Osaka Dental University, Osaka, Japan
4Department of Oral Science, Graduate School of Dentistry,
Kanagawa Dental University, Kanagawa, Japan

J Oral Tissue Engin 2018; 15(3): 143-148.

Human Υδ T cells are subdivided into two main subsets, VΥ1 and VΥ2 T cells, based on the expression of the VΥT cell receptor (TCR) subunit. Most peripheral blood Υ9VδT cells express both VΥ2 and VΥ;9 TCR subunits. VΥ9Vδ2T cells are known to play a key role in immunity against microbial infection and tumors via recognition of non-peptide phospho-antigens. Here, we investigated the anti-gen-independent cytokine-dependent activation of ex vivo expanded VΥ9Vδ2 T cells. We found that IL-15, but not IL-2, induced cell division in ex vivo expanded VΥ9Vδ2 T cells in the absence of antigen stimulation.

Key words: IL-15, VΥ9Vδ2 T cells, proliferation

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