Journal of Oral Tissue Engineering

ORIGINAL ARTICLE
Effects on ES Cell Differentiation on the Corroded Surface of Four Silver Alloys for Dental Use

Koichi IMAI1, Tsubasa SHIRAI1, Mari AKIYAMA1, Yoshiya HASHIMOTO1, Hiroshi OSHIMA1, Masayuki ZENNYU1, Takamitsu YOSHIDA1,
Shosuke MORITA2, Tomio ISEKI2, Hiroaki YOSHIDA2,Kazuhiro MATSUMOTO2, Fumiya OGAWA3, and Kazuhiko SUESE4


1Department of Biomaterials, 2First Department of Oral and Maxillofacial Surgery,
3Department of Postgraduate Clinical Training, 4Department of Esthetic Dentistry, Osaka Dental University, Osaka, Japan



J Oral Tissue Engin 2016; 14(1): 34 - 40.

SYNOPSIS
Dental silver alloys, such as gold-silver-palladium and silver-tin alloys, are frequently used in dental practice. These alloys are examined for biological safety as medical equipment. However, their embryotoxicity in normal newborns has not been investigated. We have reported the embryotoxicity risks of alloys upon their corrosion in the oral cavity, which are different from those of their composition metals. In the present study, four types of silver alloys were examined for ES cell differentiation on their surfaces corroded with human or artificial saliva. In addition, the alloy surfaces were examined by physical scratching and further erosion in dilute hydrochloric or sulfuric acid, because the dental gold-silver-palladium alloy surfaces are resistant to natural corrosion. As a result, chemicals generated upon corrosion of the four kinds of dental silver alloys may have embryotoxicity risks, unlike those immediately after casting.

Key words: embryotoxicity, silver alloy, corrosion, ES cell, cell differentiation