Journal of Oral Tissue Engineering

ORIGINAL ARTICLE

Osteoinductive Activity of 3D-modeling Titanium Scaffold with BMP

Hironari FUYAMADA1, Shin MIYAMAE1, Tatsuhide HAYASHI2, Tatsushi KAWAI2 and Masami HATTORI1

1Department of Gerodontology, School of Dentistry,
2Department of Dental Materials Science, School of Dentistry,
Aichi Gakuin University, Nagoya, Japan


J Oral Tissue Engin 2016; 13(3): 110-116

SYNOPSIS
Various methods are used to construct the scaffolds used for bone regeneration. We built a three-dimensional (3D) porous scaffold from layers of pure titanium powder melted with a powerful electron beam. We then added bone morphogenic protein to this scaffold and examined its ability to induce new bone. The surface of the scaffold was rough and the pore size was approximately 1000 μm. Three weeks after implantation, little new bone was observed inside the scaffold, whereas much bone formation had been induced around the scaffold. This study showed that a complex 3D porous scaffold can be fabricated using the electron beam melting method, suggesting that this method is effective for the construction of optimal shapes for new bone induction.

Key words: BMP, osteoinductivity, scaffold, implantation test



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