The purpose of this study was to evaluate the novel graft material for sinus augmentation by controlled release of basic fibroblast growth factor (bFGF) and biodegradable ceramics. We grafted following 4 materials into frontal sinus of beagle dogs. 1. β-tricalcium phosphate (β-TCP) and bFGF-incorporated gelatin hydrogel microspheres, 2. β-TCP and physiological saline-incorporated gelatin hydrogel microspheres, 3. β-TCP and bFGF solution, and 4. autologous bone. Augmented bone was evaluated by soft X-ray, histlogical examination and histomorphological examination at 4 and 12 weeks after implantation. When the β-TCP and bFGF-incorporated gelatin hydrogel microspheres were grafted, newly formed bone tissue volume was larger than other groups. This finding indicated that bFGF-incorporated gelatin hydrogel microspheres enables to effectively increase bone formation. We concluded that β-TCP and bFGF-incorporated gelatin hydrogel microspheres was a novel promising graft material for sinus augmentation, since it can be easily prepared and does not require a autologous bone harvest.
Keyword: basic fibroblast growth factor, gelatin hydrogel, β-tricalcium phosphate, drug delivery system
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