Journal of the Japanese Association of Regenerative Dentistry
J Jpn Assoc Regenerative Dent Vol.4(1) pp.29-43
ISSN 1348-9615


Study of promotion recovery of wounded rat submandibular gland

Tatsuo YAMDA1, Hirotaka YAMAMOTO2 and Kenji KAKUDO2
1Graduate School of Dentistry (Oral and Maxillolfacial Surgery),Osaka Dental University
2Second Department of Oral and Maxillolfacial Surgery,Osaka Dental University

Saliva is carrying out work important for a health maintenance. Even if salivary glands get damaged, the method for recovering is not learned. This study was examining the effective recovery method of the salivary glands which got damaged.
Adult male Wistar rats were used in this study. In the experimental group, right and left submandibular glands were cut sagittally, and the mesial portions removed. Each residual salivary gland was sutured to unite cut the edges. Surgery was not performed on the control group. Analysis included salivary gland weight, volume, findings on H-E stain ,saliva secretion ability, and gene analysis.
Submandibular gland of an experimental group became large volume eight weeks after, with keeping secrete saliva function .
Reservation of the number of acinar cells needed and discharge of enough saliva were considered to have promoted the regeneration of a submandibular gland.
When the damaged rats salivaly gland were connected to opposite at each other, redual acinar cells proliferation, and the saliva was possible to discharge. These data were considered to have promoted the regeneration of a submandibular gland.

Keywords: salivaly gland, regeneration, recovery promotion