Journal of the Japanese Association of Regenerative Dentistry
J Jpn Assoc Regenerative Dent Vol.4(1) pp.15-28
ISSN 1348-9615


Effect of PRP (Platelet-rich Plasma) on Alveolar Bone Placed Dental Implants with Different Surface

Yasuhiro TAJIME1 and Kenji KAKUDO2
1Graduate School of Dentistry (Oral and Maxillolfacial Surgery),Osaka Dental University
2Second Department of Oral and Maxillolfacial Surgery,Osaka Dental University

The purpose of this study was to evaluate the effects of superficial properties of implants and PRP on the alveolar bone around dental implants. Bone defects, similar to tooth-extracted holes, were made in 6 beagles, and dental implants with various superficial characteristics (Ha-coated and acid-blasted) were implanted at the center of bone defects. PRP and autologous bone were filled around the implants. Calcein- and alizarin red-labeling was performed, and new bone formation was serially observed by confocal laser scanning microscopy (CLSM) and micro-focus X-ray CT. As a result, newly formed bone was partially observed around the implant body 2 weeks after surgery, and there was a callus 4 weeks after surgery. Eight weeks after surgery, newly formed bone increased, and bone alteration was observed around the implant body. These findings suggested that application of PRP to autologous bone transplantation in bone defects induced early new bone formation.

Platelet-rich Plasma (PRP), HA-coated implant, confocal laser scanning microscopy (CLSM), microfocus X-ray CT